| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
CARDIOVASCULAR MEDICINE |
Medicines Monitoring Unit, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
Correspondence to:
Correspondence to:
Professor T M MacDonald, MEMO, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK;
t.m.macdonald{at}dundee.ac.uk
Objective: To investigate patients' adherence to statin treatment prescribed following their first myocardial infarction (MI) and to estimate the effect of adherence to statins on recurrence of MI and all cause mortality.
Design: Cohort study using a record linkage database.
Setting: Tayside, Scotland, UK.
Patients: Patients who experienced their first MI between January 1990 and November 1995.
Main outcome measures: Percentage of statin use and adherence to statins by patients after an MI and the relative risk of hospitalisation for recurrent MI. The effect of adherence on all cause mortality was also examined. The covariates used were age, sex, socioeconomic deprivation, serum cholesterol concentration, diabetes mellitus, cardiovascular drug use, and other hospitalisations.
Results: Of 5590 patients who experienced an incident MI, 717 (12.8%) experienced at least one further MI. Only 7.7% of patients used statins after an MI during the study period. Compared with those not taking statins, those who had 80% or better adherence to statin treatment had an adjusted relative risk of recurrent MI of 0.19 (95% confidence interval (CI) 0.08 to 0.47) and all cause mortality of 0.47 (95% CI 0.22 to 0.99). There was no significant reduction in either end point for those who were less than 80% adherent to statins.
Conclusions: Despite the infrequent use of statin during the study period, good adherence to statin treatment was associated with lower risk of recurrent MI.
Keywords: statin; adherence; myocardial infarction; risk factors
Abbreviations: 4S, Scandinavian simvastatin survival study; AFCAPS, Air Force coronary atherosclerosis prevention study; CARE, cholesterol and recurrent events; CHD, coronary heart disease; LIPID, long-term intervention with pravastatin in ischaemic disease; MI, myocardial infarction; WOSCOPS, West of Scotland coronary prevention study
Relevant Articles
Heart 2007 93: 902.
Heart 2006 92: 974.
This article has been cited by other articles:
|
|
 |
|
  H. S. Yin, B. P. Dreyer, L. van Schaick, G. L. Foltin, C. Dinglas, and A. L. Mendelsohn Randomized Controlled Trial of a Pictogram-Based Intervention to Reduce Liquid Medication Dosing Errors and Improve Adherence Among Caregivers of Young Children Arch Pediatr Adolesc Med, September 1, 2008; 162(9): 814 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Goldman, A. B. Jena, T. Philipson, and E. Sun Drug Licenses: A New Model For Pharmaceutical Pricing Health Aff., January 1, 2008; 27(1): 122 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Natarajan, R. W. Putnam, A. M. Yip, and D. Frail Family practice patients' adherence to statin medications Can Fam Physician, December 1, 2007; 53(12): 2144 - 2145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N Rasmussen, G. H Gislason, S. Rasmussen, S. Z Abildstrom, T. K Schramm, L. Kober, F. Diderichsen, M. Osler, C. Torp-Pedersen, and M. Madsen Use of statins and beta-blockers after acute myocardial infarction according to income and education J Epidemiol Community Health, December 1, 2007; 61(12): 1091 - 1097. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Schedlbauer, K Schroeder, and T Fahey How can adherence to lipid-lowering medication be improved? A systematic review of randomized controlled trials Fam. Pract., August 1, 2007; 24(4): 380 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Frost, H. Petersen, K. Tollestrup, and B. Skipper Influenza and COPD Mortality Protection as Pleiotropic, Dose-Dependent Effects of Statins Chest, April 1, 2007; 131(4): 1006 - 1012. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. Rasmussen, A. Chong, and D. A. Alter Relationship Between Adherence to Evidence-Based Pharmacotherapy and Long-term Mortality After Acute Myocardial Infarction JAMA, January 10, 2007; 297(2): 177 - 186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J.A. Penning-van Beest, F. Termorshuizen, W. G. Goettsch, O. H. Klungel, J. J.P. Kastelein, and R. M.C. Herings Adherence to evidence-based statin guidelines reduces the risk of hospitalizations for acute myocardial infarction by 40%: a cohort study Eur. Heart J., January 2, 2007; 28(2): 154 - 159. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Ho, J. S. Rumsfeld, F. A. Masoudi, D. L. McClure, M. E. Plomondon, J. F. Steiner, and D. J. Magid Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus. Arch Intern Med, September 25, 2006; 166(17): 1836 - 1841. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Cooke, J. L. Bresette, and R. Khanna Statin use in American Indians and Alaska Natives with coronary artery disease. Am. J. Health Syst. Pharm., September 15, 2006; 63(18): 1717 - 1722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. LaFleur, C. J Thompson, V. N Joish, S. L Charland, G. M Oderda, and D. I Brixner Adherence and Persistence with Single-Dosage Form Extended-Release Niacin/Lovastatin Compared with Statins Alone or in Combination with Extended-Release Niacin Ann. Pharmacother., July 1, 2006; 40(7): 1274 - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L Wei, M J Murphy, and T M MacDonald Impact on cardiovascular events of increasing high density lipoprotein cholesterol with and without lipid lowering drugs Heart, June 1, 2006; 92(6): 746 - 751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Andersson, A. Melander, C. Svensson, O. Lind, and J. L. G. Nilsson Repeat prescriptions: refill adherence in relation to patient and prescriber characteristics, reimbursement level and type of medication Eur J Public Health, December 1, 2005; 15(6): 621 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Katon, C. R. Cantrell, M. C. Sokol, E. Chiao, and J. M. Gdovin Impact of Antidepressant Drug Adherence on Comorbid Medication Use and Resource Utilization Arch Intern Med, November 28, 2005; 165(21): 2497 - 2503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M O'Dell and S. N Kucukarslan Impact of the Clinical Pharmacist on Readmission in Patients with Acute Coronary Syndrome Ann. Pharmacother., September 1, 2005; 39(9): 1423 - 1427. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wei, S. Ebrahim, C. Bartlett, P. D Davey, F. M Sullivan, and T. M MacDonald Statin use in the secondary prevention of coronary heart disease in primary care: cohort study and comparison of inclusion and outcome with patients in randomised trials BMJ, April 9, 2005; 330(7495): 821. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Parris, D. B. Lawrence, L. A. Mohn, and L. B. Long Adherence to Statin Therapy and LDL Cholesterol Goal Attainment by Patients With Diabetes and Dyslipidemia Diabetes Care, March 1, 2005; 28(3): 595 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Minerva BMJ, October 6, 2003; 327(7418): E168 - 168. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Buse Statin Treatment in Diabetes Mellitus Clin. Diabetes, October 1, 2003; 21(4): 168 - 172. [Full Text] [PDF]
|
|
|
|
|
|
Minerva BMJ, August 31, 2002; 325(7362): 502 - 502. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
