You are here

Article Text

Article menu
Download PDFPDF
Heart review
Connexin 43 signalling and cardioprotection
  1. K Boengler,
  2. R Schulz,
  3. G Heusch
  1. Institut für Pathophysiologie, Universitätsklinikum Essen, Essen, Germany
  1. Correspondence to:
    Professor Gerd Heusch
    Institut für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany; Gerd.heusch{at}uni-essen.de

Abstract

Connexin (Cx) 43 is the predominant protein forming gap junctions and non-junctional hemichannels in ventricular myocardium. The Cx43 proteins are central to the cardioprotection afforded by ischaemic preconditioning (IP). The specific role of mitochondrial C×43 in protection by IP is reviewed.

  • Cx, connexin
  • IP, ischaemic preconditioning
  • PKC, protein kinase C
  • ROS, reactive oxygen species
  • TOM, translocase of the outer membrane

https://doi.org/10.1136/hrt.2005.066878

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Published Online First 30 December 2005