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Workload at the heart rate of 100 beats/min and mortality in middle-aged men with known or suspected coronary heart disease

¹ Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
² Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
³ Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
⁴ School of Public Health and Clinical Nutrition, University of Kuopio, Kuopio, Finland
⁵ Inner Savo Health Centre, Suonenjoki, Finland
⁶ Oy Jurilab Ltd, Kuopio, Finland

Correspondence to:
Dr K P Savonen, Kuopio Research Institute of Exercise Medicine, Haapaniementie 16, 70100 KUOPIO, Finland; savonen{at}hytti.uku.fi

Objective: To investigate whether a workload which an individual is able to perform at the heart rate (HR) of 100 beats/min (WL₁₀₀) independently predicts mortality in middle-aged men with known or suspected coronary heart disease (CHD).

Design: Prospective population-based study based on 365 middle-aged men with known or suspected CHD at baseline.

Results: During an average follow-up of 11.1 years, there were 75 deaths (20.5%). In Cox multivariable models mortality increased by 72% (95% CI 32% to 122%, p<0.001) with 1 SD (34 Watts) decrement in WL₁₀₀ after adjustment for age, examination year, alcohol consumption, body mass index, cigarette smoking, cardiac insufficiency, history of myocardial infarction, diabetes, myocardial ischaemia during exercise test, serum low-density lipoprotein and high-density lipoprotein cholesterol, systolic and diastolic blood pressure at rest, testing protocol, and use of HR-lowering medication. The risk of death was 2.4 (95% CI 1.5 to 4.0, p<0.001) times higher in 130 men with WL₁₀₀ <55 W than in 235 men with WL₁₀₀ 55 W. In men using and not using HR-lowering medication the risk of death increased 72% (95% CI 14% to 163%, p = 0.01), and 54% (95% CI 14% to 108%, p = 0.005) with 1 SD decrement in WL₁₀₀, respectively. WL₁₀₀ improved the predictive power of the adjusted Cox models including other HR and exercise test variables.

Conclusions: WL₁₀₀ predicts mortality in men with known or suspected CHD. The association of WL₁₀₀ with mortality was not explained by other well-established HR and exercise test variables. WL₁₀₀ is derived from a submaximal test which avoids the cardiovascular risks associated with a high-intensity exertion.

This article has been cited by other articles:

				K. P. Savonen, V. Kiviniemi, J. A. Laukkanen, T. A. Lakka, T. H. Rauramaa, J. T. Salonen, and R. Rauramaa Chronotropic incompetence and mortality in middle-aged men with known or suspected coronary heart disease Eur. Heart J., August 1, 2008; 29(15): 1896 - 1902. [Abstract] [Full Text] [PDF]