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End points in clinical trials: are they moving the goalposts?

Abstract

In selecting and defining composite end points in clinical trials, are we trading off clinical significance for statistical significance?

  • CABG, coronary artery bypass graft surgery
  • CK, creatine kinase
  • MI, myocardial infarction
  • PCI, percutaneous coronary intervention
  • clinical trials
  • coronary heart disease
  • end points

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