Footnotes

• Competing interests Dr. Bisognano has received research grants and honoraria from CVRx, the manufacturer of the Rheos and Neo systems and serves as a consultant and member of scientific advisory boards for CVRx. Minimal assistance with diagrams was obtained from CVRx.

• Ethics approval The clinical trials summarised in this editorial were all approved by the appropriate local institutional review boards and, if necessary, ethics boards.

• Provenance and peer review Commissioned; internally peer reviewed.