The risk of adiposity in the presence or absence of cardiometabolic dysfunction on vascular and all-cause mortality
| Events/n | Age and sex adjusted HR | Multivariable adjusted HR* | |
|---|---|---|---|
| All-cause mortality | |||
| Normal weight | |||
| Without CMD | 128/1056 | 1 | 1 |
| With CMD | 176/717 | 1.73 (1.38 to 2.17) | 1.41 (1.12 to 1.78) |
| Overweight | |||
| Without CMD | 114/1084 | 1.00 (0.78 to 1.29) | 1.03 (0.80 to 1.33) |
| With CMD | 252/1524 | 1.27 (1.03 to 1.57) | 1.13 (0.91 to 1.40) |
| Obese | |||
| Without CMD | 14/212 | 0.81 (0.47 to 1.41) | 0.88 (0.51 to 1.53) |
| With CMD | 85/639 | 1.51 (1.15 to 2.00) | 1.37 (1.04 to 1.82) |
| Vascular mortality | |||
| Normal weight | |||
| Without CMD | 56/1056 | 1 | 1 |
| With CMD | 100/717 | 2.26 (1.63 to 3.14) | 1.74 (1.25 to 2.42) |
| Overweight | |||
| Without CMD | 57/1084 | 1.14 (0.79 to 1.65) | 1.18 (0.82 to 1.71) |
| With CMD | 131/1524 | 1.52 (1.11 to 2.09) | 1.29 (0.94 to 1.77) |
| Obese | |||
| Without CMD | 8/212 | 1.05 (0.50 to 2.21) | 1.20 (0.57 to 2.53) |
| With CMD | 47/639 | 1.94 (1.31 to 2.87) | 1.70 (1.15 to 2.52) |
CMD, cardiometabolic dysfunction (≥3 risk factors). Risk factors: (i) elevated blood pressure (≥130 mm Hg SBP and/or ≥85 mm Hg DBP, (ii) hypertriglyceridaemia (≥1.70 mmol/L), (iii) low HDL (<1.03 mmol/L for men and <1.30 for women), (iv) high fasting glucose (>5.6 mmol/L) and (v) elevated hsCRP (≥2 mg/L).
*Multivariable model adjusted for age, sex, smoking status, alcohol consumption, physical activity, use of lipid lowering agents, use of antiplatelet agents, number of affected vascular territories and years since first vascular event.
hsCRP, high-sensitivity C-reactive protein.