Incidence rate and HR of SCD in relation to waist to hip ratio categories in ARIC, stratified by smoking status
| Waist to hip ratio categories* | |||||
|---|---|---|---|---|---|
| Reference | High category 1 | High category 2 | High category 3 | P for trend | |
| Non-smokers | |||||
| N | 2743 | 2773 | 3009 | 2511 | |
| SCD cases | 25 | 19 | 46 | 60 | |
| Person-years | 35 193 | 35 707 | 38 614 | 31 186 | |
| SCD incidence† | 0.37 | 0.44 | 0.87 | 1.43 | |
| Model 1 HR‡ | 1 (ref) | 1.15 (0.63 to 2.11) | 2.29 (1.39 to 3.77) | 3.54 (2.15 to 5.81) | <0.0001 |
| Model 2 HR§ | 1 (ref) | 1.00 (0.54 to 1.84) | 1.47 (0.88 to 2.46) | 2.03 (1.19 to 3.46) | 0.003 |
| Current smokers | |||||
| N | 995 | 947 | 1031 | 932 | |
| SCD cases | 26 | 15 | 36 | 26 | |
| Person-years | 11 896 | 11 660 | 12 547 | 11 056 | |
| SCD incidence† | 1.34 | 1.28 | 2.64 | 2.07 | |
| Model 1 HR‡ | 1 (ref) | 0.96 (0.50 to 1.85) | 1.96 (1.15 to 3.33) | 1.48 (0.83 to 2.63) | 0.04 |
| Model 2 HR§ | 1 (ref) | 0.71 (0.36 to 1.37) | 1.27 (0.73 to 2.21) | 0.76 (0.41 to 1.42) | 0.78 |
*Reference: <0.80 (women); < 0.95 (men).
High category 1: 0.80–0.87 (women); 0.95–0.974 (men).
High category 2: 0.88–0.94 (women); 0.975–1.009 (men).
High category 3: 0.95–1.29 (women); 1.01–1.39 (men).
†Per 1000 person-year. Adjusted for age, sex, and race.
‡Model 1: Cox proportional hazard model adjusted for age, sex and race, field centre, education level.
§Model 2: Model 1+ adjustment for SBP, antihypertensive medication use, diabetes, LDLc, HDLc, triglycerides, prevalent CHD, prevalent heart failure, resting heart rate on ECG and LVH at baseline ECG.ARIC, Atherosclerosis Risk in Communities; CHD, coronary heart disease; HDLc, high density lipoprotein cholesterol; LDLc, low density lipoprotein cholesterol; LVH, LV hypertrophy; SBP, systolic blood pressure; SCD, sudden cardiac death.