Incidence rate and HR of SCD in relation to waist circumference categories in ARIC, stratified by smoking status
| Waist circumference categories* | |||||
|---|---|---|---|---|---|
| Reference | High category 1 | High category 2 | High category 3 | P for trend | |
| Non-smokers | |||||
| N | 4968 | 1988 | 2044 | 2036 | |
| SCD cases | 58 | 22 | 24 | 46 | |
| Person-years | 63 865 | 25 359 | 26 000 | 25 477 | |
| SCD incidence† | 0.56 | 0.68 | 0.71 | 1.08 | |
| Model 1 HR‡ | 1 (ref) | 1.22 (0.74 to 2.01) | 1.25 (0.76 to 2.03) | 2.35 (1.56 to 3.54) | 0.0002 |
| Model 2 HR§ | 1 (ref) | 0.89 (0.54 to 1.48) | 0.89 (0.54 to 1.47) | 1.27 (0.81 to 2.00) | 0.36 |
| Current smokers | |||||
| N | 2101 | 650 | 636 | 518 | |
| SCD cases | 59 | 19 | 15 | 10 | |
| Person-years | 25 125 | 7989 | 7797 | 6246 | |
| SCD incidence† | 1.81 | 2.35 | 1.83 | 1.19 | |
| Model 1 HR‡ | 1 (ref) | 1.25 (0.73 to 2.13) | 0.99 (0.55 to 1.77) | 0.75 (0.38 to 1.49) | 0.53 |
| Model 2 HR§ | 1 (ref) | 1.05 (0.60 to 1.83) | 0.65 (0.35 to 1.20) | 0.42 (0.20 to 0.85) | 0.01 |
*Reference: <88 cm (women); <102 cm (men).
High category 1: 88–95 cm (women); 102–105 cm (men).
High category 2: 96–106 cm (women); 106–111 cm (men).
High category 3: 107–168 cm (women); 112–178 cm (men).
†Per 1000 person-year. Adjusted for age, sex, and race.
‡Model 1: Cox proportional hazard model adjusted for age, sex and race, field centre, education level.
§Model 2: Model 1+ adjustment for SBP, antihypertensive medication use, diabetes, LDLc, HDLc, triglycerides, prevalent CHD, prevalent heart failure, resting heart rate on ECG and LVH at baseline ECG.ARIC, Atherosclerosis Risk in Communities; CHD, coronary heart disease; HDLc, high density lipoprotein cholesterol; LDLc, low density lipoprotein cholesterol; LVH, LV hypertrophy; SBP, systolic blood pressure; SCD, sudden cardiac death.