Reclassification analysis, for the endpoint of in-hospital mortality, using continuous reclassification showing the net reclassification index (NRI) of adding N-terminal pro B-type natriuretic peptide (NT-proBNP) or trimethylamine N-oxide (TMAO) to the classification using ADHERE (left), OPTIMIZE-HF (centre) and GWTG-HF (right) scoring only, and for adding TMAO to the classification using the clinical risk algorithm scoring with NT-proBNP
| In-hospital mortality | ||||||||
|---|---|---|---|---|---|---|---|---|
| Adding NT-proBNP to ADHERE | Adding NT-proBNP to OPTIMIZE-HF | Adding NT-proBNP to GWTG | ||||||
| Endpoint | NRI (95% CI) | p Value | Endpoint | NRI (95% CI) | p Value | Endpoint | NRI (95% CI) | p Value |
| No | −4.2 (−10.8 to 2.3) | NS | No | −10.9 (−17.8 to −4.1) | 0.002 | No | −7.8 (−14.7 to 1.0) | 0.025 |
| Yes | 19.4 (−3.7 to 42.5) | NS | Yes | 35.3 (11.5 to 59.1) | 0.004 | Yes | 11.8 (−12.0 to 35.5) | NS |
| Total | 15.2 (−8.8 to 39.2) | NS | Total | 24.4 (−0.4 to 49.1) | NS | Total | 3.9 (−20.8 to 28.7) | NS |
| Adding TMAO to ADHERE | Adding TMAO to OPTIMIZE-HF | Adding TMAO to GWTG | ||||||
| Endpoint | NRI (95% CI) | p Value | Endpoint | NRI (95% CI) | p Value | Endpoint | NRI (95% CI) | p Value |
| No | 17.8 (11.2 to 24.3) | <0.0005 | No | 23.3 (16.5 to 30.2) | <0.0005 | No | 20.5 (13.7 to 27.3) | <0.0005 |
| Yes | 8.3 (−14.8 to 31.4) | NS | Yes | 13.0 (−10.6 to 36.6) | NS | Yes | 7.2 (−16.3 to 30.8) | NS |
| Total | 26.1 (2.1 to 50.1) | 0.033 | Total | 36.4 (11.8 to 60.9) | 0.004 | Total | 27.8 (3.2 to 52.3) | 0.027 |
| Adding TMAO to ADHERE and NT-proBNP | Adding TMAO to OPTIMIZE-HF and NT-proBNP | Adding TMAO to GWTG and NT-proBNP | ||||||
| Endpoint | NRI (95% CI) | p Value | Endpoint | NRI (95% CI) | p Value | Endpoint | NRI (95% CI) | p Value |
| No | 15.6 (9.0 to 22.1) | <0.0005 | No | 17.1 (10.2 to 23.9) | <0.0005 | No | 17.2 (10.3 to 24.0) | <0.0005 |
| Yes | 11.1 (−12.0 to 34.2) | NS | Yes | 14.7 (−9.1 to 38.5) | NS | Yes | 11.8 (−12.0 to 35.5) | NS |
| Total | 26.7 (2.7 to 50.7) | 0.029 | Total | 31.8 (7.0 to 56.5) | 0.012 | Total | 28.9 (4.2 to 53.7) | 0.022 |